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Polley, Mei-Yin
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overview Dr. Polley’s primary research involves the design, conduct, and analysis of all phases of cancer clinical trials. She is the Head of the Statistics Division of NRG Oncology Statistics and Data Management Center (SDMC) as well as the Co-Chair of the Brain Tumor Committee of NRG Oncology, a National Cancer Institute sponsored member of the national clinical trials network group. Previously, she served as the Director of the Biostatistics and Bioinformatics Core of the Mayo Clinic Breast Cancer Specialized Program of Research Excellence (SPORE). Dr. Polley had served on many scientific governing or advisory bodies including the National Cancer Institute Steering Committees (breast, lymphoma, head and neck cancer, and pediatric and adolescent solid tumor), the Scientific Program Committee of American Society of Clinical Oncology (ASCO) annual meetings, and the US Veterans Affairs (VA) Oncology A Study Section. Dr. Polley’s methodological interests include early-phase clinical trial designs, biomarker reproducibility, innovative group sequential methods for biomarker validation, prognostic and predictive modeling, design and analysis of biomarker-based clinical trials, and design and monitoring of late phase clinical trials.
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Item TypeName
Concept Alleles
Concept Computer Simulation
Concept Carcinoma, Non-Small-Cell Lung
Concept Evaluation Studies as Topic
Concept Drug Synergism
Concept Health Services Needs and Demand
Concept Nervous System Diseases
Concept Neoplasm Staging
Concept Sensation Disorders
Concept Magnetic Resonance Spectroscopy
Concept Sulfatases
Concept Radiation-Sensitizing Agents
Concept Supratentorial Neoplasms
Concept Cohort Studies
Concept Spinal Neoplasms
Concept Sensitivity and Specificity
Concept Societies, Medical
Concept Sulfites
Concept Software
Concept Statistics as Topic
Concept United States
Concept Survival
Concept Tumor Stem Cell Assay
Concept Sulfotransferases
Concept Central Nervous System Neoplasms
Concept Case-Control Studies
Concept Sample Size
Concept Heparan Sulfate Proteoglycans
Concept In Situ Hybridization, Fluorescence
Concept Biological Specimen Banks
Concept Genes, p16
Concept Surveys and Questionnaires
Concept National Cancer Institute (U.S.)
Concept Serine
Concept Specimen Handling
Concept Sulfonamides
Concept High-Throughput Screening Assays
Concept TOR Serine-Threonine Kinases
Concept Models, Statistical
Concept Survival Analysis
Concept Genes, myc
Concept Patient Satisfaction
Concept Survival Rate
Concept Karnofsky Performance Status
Concept Gene Silencing
Concept Statistics, Nonparametric
Concept Tumor Suppressor Proteins
Concept Transcriptome
Concept Intracellular Signaling Peptides and Proteins
Concept Cell Survival
Concept Data Interpretation, Statistical
Concept Drug Administration Schedule
Concept Follow-Up Studies
Concept Longitudinal Studies
Concept Prospective Studies
Concept Retrospective Studies
Concept Signal Transduction
Concept Tumor Suppressor Protein p53
Concept Tumor Necrosis Factor Receptor Superfamily, Member 7
Concept Sickness Impact Profile
Concept Disease-Free Survival
Concept Polymorphism, Single Nucleotide
Academic Article Randomized Trial of Standard Adjuvant Chemotherapy Regimens Versus Capecitabine in Older Women With Early Breast Cancer: 10-Year Update of the CALGB 49907 Trial.
Academic Article A Validated T Cell Radiomics Score Is Associated With Clinical Outcomes Following Multisite SBRT and Pembrolizumab.
Award or Honor Receipt Merck & Co., Inc. Fellowship
Award or Honor Receipt The Joseph L. Fleiss Memorial Prize in Biostatistics for an Outstanding Dissertation
Award or Honor Receipt REAC Pilot Research Award in Basic and Clinical/Translational Sciences
Award or Honor Receipt Distinguished Achievement Award
Award or Honor Receipt Breast Cancer Specialized Program of Research Excellence - Developmental Research Program Award
Academic Article Dose-Adjusted EPOCH-R Compared With R-CHOP as Frontline Therapy for Diffuse Large B-Cell Lymphoma: Clinical Outcomes of the Phase III Intergroup Trial Alliance/CALGB 50303.
Academic Article Impact of histopathology, tumor-infiltrating lymphocytes, and adjuvant chemotherapy on prognosis of triple-negative breast cancer.
Academic Article En bloc resection for primary and metastatic tumors of the spine: a systematic review of the literature.
Academic Article Prognostic value of interim FDG-PET in diffuse large cell lymphoma: results from the CALGB 50303 Clinical Trial.
Academic Article Randomized phase II trial designs with biomarkers.
Academic Article Statistical and practical considerations for clinical evaluation of predictive biomarkers.
Academic Article Two-stage adaptive cutoff design for building and validating a prognostic biomarker signature.
Academic Article Impact of bevacizumab chemotherapy on craniotomy wound healing.
Academic Article Assessment of morbidity following resection of cingulate gyrus gliomas. Clinical article.
Academic Article Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma.
Academic Article Two-stage designs for dose-finding trials with a biologic endpoint using stepwise tests.
Academic Article Functional mapping-guided resection of low-grade gliomas in eloquent areas of the brain: improvement of long-term survival. Clinical article.
Academic Article The CCND1 c.870G risk allele is enriched in individuals of African ancestry with plasma cell dyscrasias.
Academic Article Hyperhaploid plasma cell myeloma characterized by poor outcome and monosomy 17 with frequently co-occurring TP53 mutations.
Academic Article Immunotherapy and radiation therapy: considerations for successfully combining radiation into the paradigm of immuno-oncology drug development.
Academic Article Power estimation in biomarker studies where events are already observed.
Academic Article An international Ki67 reproducibility study.
Academic Article Criteria for the use of omics-based predictors in clinical trials.
Academic Article Folate receptor alpha expression associates with improved disease-free survival in triple negative breast cancer patients.
Academic Article Comparison of confidence interval methods for an intra-class correlation coefficient (ICC).
Academic Article Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration.
Academic Article Pediatric intracranial ependymoma: the roles of surgery, radiation and chemotherapy.
Academic Article Identifying the needs of brain tumor patients and their caregivers.
Academic Article Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: a phase I study.
Academic Article Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival.
Academic Article Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme.
Academic Article A simulation based evaluation of sample size methods for biomarker studies
Academic Article Insular glioma resection: assessment of patient morbidity, survival, and tumor progression.
Academic Article Differences in genomic abnormalities among African individuals with monoclonal gammopathies using calculated ancestry.
Academic Article An international study to increase concordance in Ki67 scoring.
Academic Article Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide.
Academic Article Conditional probability of survival in patients with newly diagnosed glioblastoma.
Academic Article Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme.
Academic Article Development of omics-based clinical tests for prognosis and therapy selection: the challenge of achieving statistical robustness and clinical utility.
Academic Article Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma.
Academic Article An extent of resection threshold for newly diagnosed glioblastomas.
Academic Article Mass Cytometry Analysis Reveals that Specific Intratumoral CD4+ T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma.
Academic Article Randomized trial of ofatumumab and bendamustine versus ofatumumab, bendamustine, and bortezomib in previously untreated patients with high-risk follicular lymphoma: CALGB 50904 (Alliance).
Academic Article Bleomycin use in the treatment of Hodgkin lymphoma (HL): toxicity and outcomes in the modern era.
Academic Article Quality of life in low-grade glioma patients receiving temozolomide.
Academic Article Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms.
Academic Article Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study.
Academic Article Practical modifications to the time-to-event continual reassessment method for phase I cancer trials with fast patient accrual and late-onset toxicities.
Academic Article Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM.
Academic Article Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.
Academic Article Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma.
Academic Article Six-month progression-free survival as an alternative primary efficacy endpoint to overall survival in newly diagnosed glioblastoma patients receiving temozolomide.
Academic Article Survival, Pathologic Response, and Genomics in CALGB 40601 (Alliance), a Neoadjuvant Phase III Trial of Paclitaxel-Trastuzumab With or Without Lapatinib in HER2-Positive Breast Cancer.
Academic Article A clinical calculator to predict disease outcomes in women with triple-negative breast cancer.
Academic Article Statistical Considerations in the Evaluation of Continuous Biomarkers.
Academic Article Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group.
Academic Article Early-Phase Platform Trials: A New Paradigm for Dose Finding and Treatment Screening in the Era of Precision Oncology.
Academic Article Two-Stage Adaptive Design for Prognostic Biomarker Signatures With a Survival Endpoint
Academic Article Circulating levels of immune and inflammatory markers and long versus short survival in early-stage lung cancer.
Academic Article On the Quest of Risk Stratification in HER2-Positive Breast Cancer.
Academic Article Characteristics and Spatially Defined Immune (micro)landscapes of Early-stage PD-L1-positive Triple-negative Breast Cancer.
Award or Honor Receipt Appointee - Special Government Employee (SGE) member, Federal Advisory Committee Act (FACA)
Academic Article CALGB 40603 (Alliance): Long-Term Outcomes and Genomic Correlates of Response and Survival After Neoadjuvant Chemotherapy With or Without Carboplatin and Bevacizumab in Triple-Negative Breast Cancer.
Academic Article Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
Academic Article Molecular Profiling in Neuro-Oncology: Where We Are, Where We're Heading, and How We Ensure Everyone Can Come Along.
Academic Article Current drug development and trial designs in neuro-oncology: report from the first American Society of Clinical Oncology and Society for Neuro-Oncology Clinical Trials Conference.
Academic Article Two-Stage Adaptive Design for Prognostic Biomarker Signatures with a Survival Endpoint.
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